{"id":3885,"date":"2020-02-14T19:38:33","date_gmt":"2020-02-14T19:38:33","guid":{"rendered":"https:\/\/home.hamptonu.edu\/pharmacy\/?page_id=3885"},"modified":"2023-11-06T15:42:09","modified_gmt":"2023-11-06T15:42:09","slug":"dr-mikhail-l-bondarev-bio","status":"publish","type":"page","link":"https:\/\/home.hamptonu.edu\/pharmacy\/dr-mikhail-l-bondarev-bio\/","title":{"rendered":"Dr. Mikhail L. Bondarev Bio"},"content":{"rendered":"\t\t
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Dr. Mikhail L. Bondarev<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Associate Professor<\/em><\/p>

Location:<\/strong>\u00a0Biomedical Research Building II – Room\u00a0216<\/p>

Phone: <\/b>757-727-5870<\/p>

E-mail: <\/b>mikhail.bondarev@hamptonu.edu<\/a><\/p>

Expertise: <\/b>Medicinal Chemistry, Pharmacognosy, Drug Design and Development, Organic Synthesis<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Dr. Bondarev coordinates and teaches Medicinal Chemistry I (PHA 314, Spring Semester) and Medicinal Chemistry II (PHA 413, Fall Semester)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Research Interest<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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The primary goals are to design, synthesize, and evaluate novel ligands, with a particular emphasis on serotonin, nicotinic acetylcholine, and GABAA<\/sub>\u00a0(benzodiazepine site) receptors. These ligands are needed to better understand a role of receptors in the treatment of neurodegenerative disorders, addiction, psychiatric disorders, and other disorders of the central nervous system. In addition, his research involves the developments of new synthetic methodologies that allow access to the desired compounds in a highly efficient manner. Dr. Bondarev is also engaged in collaborative studies with researchers in the USA and throughout the world.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Ongoing Research Project<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\u00a0\u201cDesign and development of 5-HT7<\/sub>\u00a0receptor agonists\u201d (PI, 2013-2017, NIH\/ NIGMS)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Education<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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  • Ph.D. Synthetic Medicinal Chemistry, A.V. Bogatsky Physico-Chemical Institute of the National Academy of Sciences of Ukraine.<\/li>
  • M.S. Bioorganic\/Medicinal Chemistry, I. I. Mechnikov Odessa State University, Ukraine.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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    Post-Doctoral Experience<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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    • Visiting Scientist in the Department of Medicinal Chemistry at Virginia Commonwealth University, Richmond, VA.<\/li>
    • Postdoctoral Research Associate in the Drug Discovery Unit at Affymax Research Institute, Santa Clara, CA.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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      Selected Publications<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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      1. Shibinskaya, O. M.; Karpenko, A. S.; Lyakhov, S. A.; Andronati, S. A.; Zholobak, N. M.; Spivak N. Ya.; Samochina, N. A.; Shafran, L. M.; Zubritsky, M. Yu.;\u00a0Bondarev, M. L<\/strong>.Synthesis and Biological Activity of 1,2,3,4-Tetrahydroindolo[2,3-b]quinoxaline Derivatives.\u00a0J. Pharm. Sci. Pharmacol.<\/em>\u00a02015<\/strong>, 2, 140-147.<\/p><\/li>

      2. Glennon, R. A.; Siripurapu, U.; Roth, B.; Kolanos, R.;\u00a0Bondarev, M. L<\/strong>.; Sikazwe, D.; Lee, M.; Dukat, M. The medicinal chemistry of 5-HT6<\/sub>\u00a0receptor ligands with a focus on arylsulfonyltryptamine analogs.\u00a0Curr. Top. Med. Chem.<\/em>\u00a02010<\/strong>, 10, 579-595.<\/p><\/li>

      3. Sikazwe, D.;\u00a0Bondarev, M. L<\/strong>.; Dukat, M.; Rangisetty, J. B. Roth, B. L.; Glennon, R. A. Binding of sulfonyl-containing arylalkylamines at human 5-HT6<\/sub>\u00a0receptors.\u00a0J. Med. Chem.<\/em>\u00a02006,<\/strong>\u00a049, 5217-5225.<\/p><\/li>

      4. Pullagurla, M.; Siripurapu, U.; Kolanos, R.;\u00a0Bondarev, M. L<\/strong>.; Dukat, M.; Setola, V.; Roth, B.L.; Glennon, R. A. Binding of amino-substituted N1<\/sub>-benzenesulfonylindoles at human 5-HT6\u00a0<\/sub>serotonin receptors.\u00a0Bioorg. Med. Chem. Lett.<\/em>\u00a02005,<\/strong>\u00a015, 5298-5302.<\/p><\/li>

      5. Glennon, R.A.;\u00a0Bondarev, M. L<\/strong>.;\u00a0Khorana, N.; Young, R.; May, J. A.; Hellberg, M.R.; McLaughlin, M. A.; Sharif, N. A. \u03b2-Oxygenated analogues of the 5-HT2A<\/sub>\u00a0serotonin receptors agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane.\u00a0J. Med. Chem.<\/em>\u00a02004,<\/strong>\u00a047, 6034-6041.<\/p><\/li>

      6. Bondarev, M. L<\/strong>.; Bondareva, T.S.; Young, R.; Glennon, R. A. Behavioral and biochemical investigations of bupropion metabolites.\u00a0Eur. J. Pharmacol.<\/em>\u00a02003,<\/strong>\u00a0474, 85-93.<\/p><\/li>

      7. Rangisetty, J. B.;\u00a0Bondarev, M. L.;<\/strong>Chang-Fong, J.; Young, R.; Glennon, R. A. PMMA-stimulus generalization to the optical isomers of MBDB and 3,4-DMA.\u00a0Pharmacol., Biochem. Behav.<\/em>\u00a02001,<\/strong>\u00a069, 261-267.<\/p><\/li>

      8. Khorana, N.;\u00a0Bondarev, M.;<\/strong>\u00a0Dukat , M.; Herrick-Devis, K.; Egan, C.; DuPre, A.; Smith, C.; Teitler, M.; Glennon, R. A. Binding of spiperone analogs at 5-HT2A\u00a0<\/sub>serotonin receptors.\u00a0Med. Chem. Res.<\/em>\u00a01999<\/strong>, 9, N9, 657-667.<\/p><\/li>

      9. Westkaemper, R.B.; Runyon, S.P.;\u00a0Bondarev, M. L.;<\/strong>\u00a0Savage, J. E.; Roth, B.L.; Glennon, R.A. 9-(Aminomethyl)-9,10-dihydroanthracene is a novel and unlikely 5-HT2A<\/sub>\u00a0receptor antagonist.\u00a0Eur. J. Pharmcol.<\/em>\u00a01999,<\/strong>\u00a0380, R5-R7.<\/p><\/li>

      10. Young, R.;\u00a0Bondarev, M.;<\/strong>\u00a0Glennon, R.A. An examination of isomeric phenylpropanolamines in (-)ephedrine-trained rats.\u00a0Drug Alcohol Depend.<\/em>\u00a01999,<\/strong>\u00a051, 1-6.<\/p><\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

        Dr. Mikhail L. Bondarev Associate Professor Location:\u00a0Biomedical Research Building II – Room\u00a0216 Phone: 757-727-5870 E-mail: mikhail.bondarev@hamptonu.edu Expertise: Medicinal Chemistry, Pharmacognosy, Drug Design and Development, Organic Synthesis Dr. Bondarev coordinates and […]<\/p>\n","protected":false},"author":50,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_mc_calendar":[],"footnotes":""},"class_list":["post-3885","page","type-page","status-publish","hentry"],"yoast_head":"\nDr. Mikhail L. Bondarev Bio - School of Pharmacy<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/home.hamptonu.edu\/pharmacy\/dr-mikhail-l-bondarev-bio\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dr. Mikhail L. Bondarev Bio - School of Pharmacy\" \/>\n<meta property=\"og:description\" content=\"Dr. Mikhail L. 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