{"id":11108,"date":"2025-07-14T09:38:29","date_gmt":"2025-07-14T13:38:29","guid":{"rendered":"https:\/\/home.hamptonu.edu\/science\/?page_id=11108"},"modified":"2026-03-23T10:04:15","modified_gmt":"2026-03-23T14:04:15","slug":"elementor-11108","status":"publish","type":"page","link":"https:\/\/home.hamptonu.edu\/science\/elementor-11108\/","title":{"rendered":"Elementor #11108"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"11108\" class=\"elementor elementor-11108\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1dede06 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1dede06\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e445547\" data-id=\"e445547\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5406f5f elementor-widget elementor-widget-text-editor\" data-id=\"5406f5f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Dr. Graham Chakafana<img decoding=\"async\" class=\"size-full wp-image-11107 alignright\" src=\"http:\/\/home.hamptonu.edu\/science\/wp-content\/uploads\/sites\/47\/2025\/07\/Dr.-Chakafana-Photo.jpg\" alt=\"\" width=\"150\" height=\"150\" \/><\/strong><br \/>Assistant Professor, Department of Chemistry and Biochemistry<br \/><strong>Location<\/strong>: Turner Hall, Room 328<br \/><strong>Phone<\/strong>: 757.727.5249<br \/><strong>Email<\/strong>: graham.chakafana@hamptonu.edu<br \/><strong>Expertise<\/strong>: Protein Structure and Function, Drug Discovery<\/p><p><strong>Education<\/strong><\/p><ul><li>Postdoctoral Fellowship, Medicine, Stanford University, 2022<\/li><li>Postdoctoral Fellowship, Medicine, University of Cape Town, 2021<\/li><li>Ph.D. Protein Biochemistry, University of Venda, 2020<\/li><li>M.Sc. Microbiology (Distinction), National University of Science and Technology, 2015<\/li><li>B.Sc. (Hons) Biotechnology, Chinhoyi University of Technology, 2011<\/li><\/ul><p><strong>Courses Taught<\/strong><\/p><ul><li>Advanced Biochemistry<\/li><li>Biophysical Chemistry<\/li><li>Elementary Biochemistry<\/li><li>Research Topics in Chemistry<\/li><\/ul><p><strong>Research Interests and Expertise<\/strong><br \/>Dr. Graham Chakafana\u2019s research explores the proteomic foundations of infectious and cardiovascular diseases with the goal of identifying therapeutic targets that advance treatment options.<\/p><p><strong>Infectious Diseases<\/strong>: Dr. Chakafana\u2019s lab investigates the structural and functional properties of druggable proteins across a range of infectious diseases including <em>Plasmodium<\/em> <em>sp<\/em> that are responsible for malaria. His lab utilizes biophysical and biochemical methods to characterize putative druggable proteins from infectious agents. By targeting essential proteins in pathogens, his research seeks to disrupt critical pathways necessary for their survival, offering potential for selective therapeutic interventions that minimize harm to human cells.<\/p><p><strong>Cardiovascular Disease<\/strong>: In his cardiovascular research, Dr. Chakafana focuses on the proteomic and genetic determinants of hypertensive heart disease and Chagas disease, particularly within minority populations, to better understand the molecular drivers of these conditions and identify effective interventions.<\/p><p><strong>Links to My Research<\/strong><br \/><a href=\"https:\/\/scholar.google.com\/citations?user=S162EeUAAAAJ&amp;hl=en\">Google Scholar Profile<\/a><strong>\u00a0<\/strong><\/p><p><strong>Selected Publications<\/strong><\/p><ol><li><strong> Ternary structure of <em>Plasmodium vivax <\/em>N-myristoyl transferase (<em>Pv<\/em>NMT) with myristoyl-CoA and inhibitor IMP-0001173<\/strong><em>. Acta Crystallographica F<\/em>. 2024. C. Bolling, A. Mendez, S. Taylor, S. Makumire, A Reers, R. Zigweid, S. Subramanian, D. M. Dranow, B. Staker, T. E. Edwards, E W. Tate, A. S. Bellg, P. J. Myler, O. A. Asojo, and <u>G. Chakafana*<\/u><\/li><li><strong> Proteome profiling in patients with peripartum cardiomyopathy according to ethnicity a biomarker study on the EORP cohort.<\/strong><em>European Heart Journal<\/em>,\u00a0<em>45.<\/em> 2024. Kodogo, V., Viljoen, C., <u>Chakafana, G<\/u>., Hoevelmann, J., Jackson, A., Al-Farhan, H., Goland, S., Tromp, J., Van Der Meer, P., Karaye, K. and Kryczka, K<\/li><li><strong>Clinical presentation, risk factors and six-month outcomes in Ugandan women with peripartum cardiomyopathy: prospective case-control study.<\/strong><em>European Heart Journal<\/em>, 45. J Nabbaale, K Sliwa, E Okelo, A N Annettee and <u>G Chakafana<\/u><\/li><li><strong>Structure of <em>Plasmodium vivax<\/em> N-myristoyl transferase with inhibitor IMP-1088 &#8211; exploring an NMT inhibitor for antimalarial therapy<\/strong>. <em>ACTA Cryst<\/em>. 2025. A. Mendez, C. Bolling, S. Taylor, S. Makumire, A. Reers, R. Zigweid, S. Subramanian, D.M. Dranow, B. Staker, T.E. Edwards, E.W.Tate, A.S. Bell, P.J. Myler, O.A. Asojo and <u>G. Chakafana<\/u>*<\/li><li><strong> Structures of\u00a0<em>Brucella ovis<\/em>leucine-, isoleucine-, valine-, threonine- and alanine-binding protein reveal a conformationally flexible peptide-binding cavity. <\/strong><em>Acta Crystallographica F<\/em>. 2024. <a href=\"https:\/\/scripts.iucr.org\/cgi-bin\/citedin?search_on=name&amp;author_name=Chakafana%2C%20G%2E\">G. Chakafana<\/a><u>*<\/u>,<a href=\"https:\/\/scripts.iucr.org\/cgi-bin\/citedin?search_on=name&amp;author_name=Boswell%2C%20R%2E\">R. Boswell<\/a>,\u00a0<a href=\"https:\/\/scripts.iucr.org\/cgi-bin\/citedin?search_on=name&amp;author_name=Chandler%2C%20A%2E\">A. Chandler<\/a>,\u00a0<a href=\"https:\/\/scripts.iucr.org\/cgi-bin\/citedin?search_on=name&amp;author_name=Jackson%2C%20K%2EA%2E\">K A. Jackson<\/a>,\u00a0<a href=\"https:\/\/scripts.iucr.org\/cgi-bin\/citedin?search_on=name&amp;author_name=Neblett%2C%20S%2E\">S. Neblett<\/a>,\u00a0<a href=\"https:\/\/scripts.iucr.org\/cgi-bin\/citedin?search_on=name&amp;author_name=Postal%2C%20T%2E\">T. Postal<\/a>,\u00a0<a href=\"https:\/\/scripts.iucr.org\/cgi-bin\/citedin?search_on=name&amp;author_name=Subramanian%2C%20S%2E\">S. Subramanian<\/a>,\u00a0<a href=\"https:\/\/scripts.iucr.org\/cgi-bin\/citedin?search_on=name&amp;author_name=Abendroth%2C%20J%2E\">J. Abendroth<\/a>,\u00a0<a href=\"https:\/\/scripts.iucr.org\/cgi-bin\/citedin?search_on=name&amp;author_name=Myler%2C%20P%2EJ%2E\">P J. Myler<\/a>\u00a0and\u00a0<a href=\"https:\/\/scripts.iucr.org\/cgi-bin\/citedin?search_on=name&amp;author_name=Asojo%2C%20O%2EA%2E\">O A. Asojo<\/a>*<\/li><li><strong> Biophysical and functional characterization of an essential nucleoside diphosphate kinase from <em>Trypanosoma brucei<\/em><\/strong>. 2024. P. Makori, N. Poolsawat, F. Payne, M. Gatling, C. Greer, D. Hayes, A. Jefferson, M. Maxwell, C. Smith, J. Watson, L. Williams, J. Barkley, C. Pepper, T. Zininga, O. Pooe, L. Zuma, S. Subramanian, P. J Myler, O Asojo, <u>G. Chakafana<\/u>* [In Preparation] \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0*(student mentees shown in blue)\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/li><li><strong> Swapping the linkers of canonical Hsp70 and Hsp110 chaperones compromises both self-association and client selection. <\/strong><em>Heliyon<\/em>. 2024 <u>Chakafana, G<\/u>., Middlemiss, C.J., Zininga, T. and Shonhai, A<\/li><li><strong> Insertion of GGMP repeat residues of <em>Plasmodium falciparum<\/em> Hsp70-1 in the lid of DnaK adversely impacts client recognition.\u00a0<\/strong><em>International Journal of Biological Macromolecules<\/em>,\u00a0<em>255<\/em>. 2024. Dongola, T.H., <u>Chakafana, G<\/u>., Middlemiss, C., Mafethe, O., Mokoena, F., Zininga, T. and Shonhai, A<\/li><\/ol><p><strong>Book Chapter<\/strong><\/p><ol><li><strong>Functionalized nanobody-based delivery systems for cancer diagnosis and therapeutic applications. 2023.<\/strong> G V. Kumar, A. Manicum, T. Makwikwi, <u>G. Chakafana<\/u>, E. Agwamba, D. R. Katerere.<\/li><\/ol><p><strong>Professional Honors and Awards<\/strong><\/p><ul><li>Princeton University, Visiting Faculty Research Partnership, 2023, 2024<\/li><li>National Crystallization Center Meritorious User Award, 2023<\/li><li>UCT Faculty of Health Sciences Best Publication Award, 2021<\/li><li>NUST University Book Prize (Best MSc Student, Biochemistry), 2015<\/li><li>Vice Chancellor\u2019s Award (Best MSc Student, Applied Microbiology), 2015<\/li><li>ZOE Manufacturer\u2019s Prize (Best MSc Student, Faculty of Science), 2015<\/li><\/ul><p><strong>Professional Affiliations<\/strong><\/p><ul><li>American Society for Biochemistry and Molecular Biology (ASBMB)<\/li><li>American Heart Association (AHA)<\/li><li>Virginia Academy of Science<\/li><li>American Chemical Society<\/li><\/ul><p><strong>Editorial Board Positions<\/strong><\/p><ul><li>Associate Editor, <em>Frontiers in Molecular Biosciences<\/em><\/li><li>Associate Editor, <em>Acta Crystallographica<\/em><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Dr. Graham ChakafanaAssistant Professor, Department of Chemistry and BiochemistryLocation: Turner Hall, Room 328Phone: 757.727.5249Email: graham.chakafana@hamptonu.eduExpertise: Protein Structure and Function, Drug Discovery Education Postdoctoral Fellowship, Medicine, Stanford University, 2022 Postdoctoral Fellowship, Medicine, University of Cape Town, 2021 Ph.D. Protein Biochemistry, University of Venda, 2020 M.Sc. Microbiology (Distinction), National University of Science and Technology, 2015 B.Sc. (Hons) [&hellip;]<\/p>\n","protected":false},"author":187,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_mc_calendar":[],"footnotes":""},"class_list":["post-11108","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Elementor #11108 - School Of Science<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/home.hamptonu.edu\/science\/elementor-11108\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Elementor #11108 - School Of Science\" \/>\n<meta property=\"og:description\" content=\"Dr. Graham ChakafanaAssistant Professor, Department of Chemistry and BiochemistryLocation: Turner Hall, Room 328Phone: 757.727.5249Email: graham.chakafana@hamptonu.eduExpertise: Protein Structure and Function, Drug Discovery Education Postdoctoral Fellowship, Medicine, Stanford University, 2022 Postdoctoral Fellowship, Medicine, University of Cape Town, 2021 Ph.D. Protein Biochemistry, University of Venda, 2020 M.Sc. 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Microbiology (Distinction), National University of Science and Technology, 2015 B.Sc. 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