{"id":34,"date":"2022-09-10T20:11:50","date_gmt":"2022-09-10T20:11:50","guid":{"rendered":"https:\/\/home.hamptonu.edu\/skin\/?page_id=34"},"modified":"2024-09-20T02:02:18","modified_gmt":"2024-09-20T02:02:18","slug":"research-team","status":"publish","type":"page","link":"https:\/\/home.hamptonu.edu\/skin\/research-team\/","title":{"rendered":"Research Team"},"content":{"rendered":"\t\t
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Research Team<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Co-Directors<\/h2>\n
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Dr. Valerie Harvey<\/strong> is an Hampton University adjunct faculty member and an assistant professor of Dermatology at Eastern Virginia Medical School and a board-certified dermatologist whose areas of interest include melanoma, ethnic skin and health disparities. Harvey attended University of Virginia School of Medicine where she was inducted into the Alpha Omega Alpha (AOA) medical honor society. She completed her dermatology residency at University of Maryland in Baltimore where she also served as chief resident. Harvey was awarded a grant from the Dermatology Foundation to study the clinical and molecular aspects of post inflammatory hyperpigmentation in different racial and ethnic groups. She is the recipient of the Nethercott Research Fellowship Award and has published as well as given numerous presentations on diseases that affect individuals with skin of color.<\/p>\n<\/div>\n

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Dr. David H. McDaniel<\/strong> is an adjunct faculty member at Hampton University and an assistant professor of Clinical Dermatology at Eastern Virginia Medical School. In addition to his dermatology training, he has special training in physical chemistry, light physics, pathology, dermatopathology, botany and emergency medicine. He is the author of over 75 scientific articles and book chapters, primarily concentrating in the field of laser and cosmetic surgery, antioxidants and anti-aging medicine. McDaniel has over 25 years of clinical experience in cosmetic laser surgery and dermatology research. McDaniel helped pioneer the science and theory of LED photomodulation. More recently, McDaniel has been involved in the testing and development of several new antioxidant skin care products as well as research related to extending lifespan and healthy longevity. McDaniel has been selected by his peers to be included in the Best Doctors in America for 2009-2010 for the 15th year in a row.<\/p>\n<\/div>\n

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Scientific Director<\/h2>\n
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Dr. Joanne Chan<\/strong> currently serves as the Scientific Director of the Hampton University Skin of Color Research Institute and leads research in diseases affecting the skin. She is focused on translational studies using the zebrafish as a discovery model. Her work on vascular signaling pathways has provided valuable insights into the mechanism of human disease. Dr. Chan is currently focused on melanocyte interactions with blood vessels in development and disease. She is interested in the interaction between melanocytes and endothelial cells in regeneration and wound healing, in melanoma and in keloid formation.<\/span><\/p>\n

Dr. Chan was recruited to Hampton University from Boston Children\u2019s Hospital. As a Faculty Member at Harvard Medical School, she taught medical and graduate students. In the laboratory, Dr. Chan has supervised a number of postdoctoral fellows, research fellows, graduate students and technicians. She initiated the use of the zebrafish model for cancer research at the Dana-Farber Cancer Institute and was Director of the Enders Zebrafish Facility at the Boston Children\u2019s Hospital.<\/p>\n

Publications<\/strong><\/p>\n

Kawasaki, J., Aegerter, S., Fevurly, R.D., Mammoto, A., Mammoto, T., Sahin, M., Mably, J.D., Fishman, S.J., Chan, J. (2014) RASA1 functions in EPHB4 signaling pathway to suppress endothelial mTORC1 activity. J. Clin. Invest.<\/em>124(6):2774-84.<\/p>\n

Jia, D., Hasso, S.M., Chan, J., Filingeri, D., D’Amore, P.A., Rice, L., Pampo, C., Siemann, D.W., Zurakowski, D., Rodig, S.J., and Moses, M.A. (2013) Transcriptional repression of VEGF by ZNF24: mechanistic studies and vascular consequences in vivo. Blood <\/em>121(4):707-715.<\/p>\n

Fevurly, R.D., Hasso, S., Fye, A., Fishman, S.J., and Chan, J. (2012) Novel zebrafish model reveals a critical role for MAPK in lymphangiogenesis. J. Pediatr. Surg.<\/em> 47(1):177-182.<\/p>\n

Chan, J., and Mably, J.D. (2011) Dissection of cardiovascular development and disease pathways in zebrafish. Prog. Mol. Biol. Transl. Sci.<\/em>100:111-153.<\/p>\n

Hasso, S., and Chan, J. (2011) Chemical approaches to angiogenesis in development and regeneration. Meth. Cell. Biol.<\/em>101:181-195.<\/p>\n

Bolcome, R.E. 3rd, and Chan, J. (2010) Constitutive MEK1 Activation Rescues Anthrax Lethal Toxin Induced Vascular Effects In Vivo. Infect. Immun<\/em>. 78(12):5043-5053.<\/p>\n

Vasil, M.L., Stonehouse, M.J., Vasil, A.I., Wadsworth, S.J., Goldfine, H., Bolcome, R.E. 3rd, and Chan, J. (2009) A complex extracellular sphingomyelinase of Pseudomonas aeruginosa inhibits angiogenesis by selective cytotoxicity to endothelial cells. PLoS Pathog<\/em> .5(5):e1000420.<\/p>\n

Bolcome, R.E. 3rd, Sullivan, S.E., Zeller, R., Barker, A.P., Collier, R.J., and Chan, J. (2008) Anthrax lethal toxin induces cell death-independent permeability in zebrafish vasculature. Proc. Natl. Acad. Sci. USA<\/em> 105(7):2439-2444.<\/p>\n

Juris, S.J., Melnyk, R.A., Bolcome, R.E., Chan, J., and Collier, R.J (2007) Crosslinked Forms of the Isolated N-terminal Domain of the Lethal Factor are Potent Inhibitors of Anthrax Toxin. Infect. Immun.<\/em> 75(10):5052-5058.<\/p>\n

Ho, D.M., Chan, J., Bayliss, P., and Whitman, M. (2006) Inhibitor-resistant type I receptors reveal specific requirements for TGF-beta signaling in vivo. Dev. Biol<\/em>. 295(2):730-742.<\/p>\n

Chan, J., and Serluca, F.C. (2004) Chemical approaches to angiogenesis, The Zebrafish: Cellular and Developmental Biology, 2nd Ed. Methods Cell Biol.<\/em>76:475-487.<\/p>\n

Wagle, M., Grunewald, B., Subburaju, S., Barzaghi, C., Le Guyader, S., Chan, J., and Jesuthasan, S. (2004) EphrinB2a in the zebrafish retinotectal system. J. Neurobiol.<\/em> 59(1):57-65.<\/p>\n

Montero, J.-A., Killan, B., Chan, J., Bayliss, P.E., and Heisenberg, C.-P. (2003) Phosphoinositide 3-kinase is required for process outgrowth and cell polarization of gastrulating mesendodermal cells. Curr. Biol.<\/em> 13 (15):1279-1289.<\/p>\n

Chan, J., Bayliss, P.E., Wood, J.M., and Roberts, T.M. (2002) Dissection of angiogenic signaling in zebrafish using a chemical genetic approach. Cancer Cell<\/em> 1(3):257-267.<\/p>\n

Chan, J., Mably, J.D., Serluca, F.C., Chen, J.-N., Goldstein, N.B., Thomas, M.C., Cleary, J.A., Brennan, C., Fishman, M.C., and Roberts, T.M. (2001) Morphogenesis of prechordal plate and notochord requires intact Eph\/Ephrin B signaling. Dev. Biol.<\/em> 234(2):470-482.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Research Team Co-Directors Dr. Valerie Harvey is an Hampton University adjunct faculty member and an assistant professor of Dermatology at Eastern Virginia Medical School and a board-certified dermatologist whose areas of interest include melanoma, ethnic skin and health disparities. 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