Patrick Hines is a scientist and physician who has spent over 20 years investigating the mechanisms regulating microvascular blood flow in sickle cell disease. He has authored numerous publications in this field and was among the first to describe the ability of soluble stress mediators to rapidly increase adhesive properties of sickle erythrocytes. He is internationally recognized for his efforts to develop and validate a gold standard for the assessment of red blood cell health in clinical practice, work that grew out of patient care challenges he experienced as a pediatric intensivist.