Dr. Graham Chakafana Assistant Professor, Chemistry and Biochemistry
Location: Turner Hall 318
Phone: 757.727.5249
E-mail: graham.chakafana@hamptonu.edu
Expertise: protein structure and function, drug discovery
Bio:
Education:
Postdoctoral Fellowship- Medicine, 2022 Stanford University
Postdoctoral Fellowship- Medicine, 2021 University of Cape Town
PhD Protein Biochemistry, 2020 University of Venda
MSc Microbiology (Distinction), 2015 National University of Science and Technology
BSc (Hons) Biotechnology, 2011 Chinhoyi University of Technology
Chemistry Courses taught:
Biochemistry, Biophysical chemistry, Research topics in Chemistry
Research Interests and Expertise:
My research generally focuses on the structure and functions of heat shock proteins (Hsps) in malaria and cardiac disease with the goal of targeting select Hsps towards drug development.
Links to my Research
Selected Publications
- Characterisation of a novel linker segment of the Plasmodium falciparum cytosol localised Hsp110 chaperone. 2021. International Journal of Biological Macromolecules. G. Chakafana, P. T. Mudau, T. Zininga, A. Shonhai
- E. coli-based complementation assay and biochemical analyses reveal an essential role of the GGMP motif of Plasmodium falciparum Hsp70-1 chaperone. 2021. International Journal of Molecular Sciences. S. Makumire, T. Dongola, G. Chakafana, L. Tshikonwane, C.T. Chauke, T. Maharaj, T. Zininga, A. Shonhai
- Heat shock proteins: potential modulators and candidate biomarkers of peripartum cardiomyopathy. 2021. Frontiers in Cardiovascular Medicine. G. Chakafana, T. F. Spracklen, S. Kamuli, T. Zininga, A. Shonhai, N. A. B. Ntusi, K Sliwa
- The role of non-canonical Hsp70s (Hsp110/Grp170) in cancer. 2021. Cells. G. Chakafana, A. Shonhai
- Interplay of COVID19 and cardiovascular diseases in Africa: an observational screenshot. 2020. Clinical Research in Cardiology. G. Chakafana, D. Mutithu, J. Hovelmann, N. A. B. Ntusi, K. Sliwa
- Plasmodium falciparum R2TP complex: drivers of parasite Hsp90s. 2019. Biophysical Reviews. T. V. Seraphim, G. Chakafana, A. Shonhai, W. A. Houry
- Elucidating the common and unique features of P. falciparum and human Hsp70s. 2019. Biophysical Reviews. G. Chakafana, T. Zininga, A. Shonhai
- The link that binds: the linker of Hsp70 as a helm of protein function. 2019. Biomolecules. G. Chakafana, T. Zininga, A. Shonhai
Professional Honors and Awards
- UCT, Department of Medicine Fund recipient (2021)
- UCT, Faculty of Health Sciences best publication award (2021)
- UCT, University Research Council Postdoctoral Fellowship (2020)
- NRF (National Research Foundation-RSA) Doctoral Study Scholarship (2017)
- DFG (German Research Foundation) Germany-Africa Infectiology initiative award for PhD study (2016)
- NUST University Book Prize (Best MSc student-Biochemistry Dept, 2015)
- Vice Chancellor’s Award (Best MSc student-Applied Microbiology, 2015)
- ZOE Manufacturer’s Prize (Best MSc student-Faculty of Science, 2015)
Professional Affiliations:
- ASBMB (American Association and of Biochemistry and Molecular Biology)
- ESC (European Society of Cardiology)
- AHA (American Heart Association)
- Virginia Academy of Science
- American Chemical Society
Journal Editorial Boards:
- Associate Editor, Frontiers in Molecular Biosciences
